{"data":{"puzzle":{"title":"[Thermocycler] Level 1 of 11","created":"Feb 14, 2013","object":"[{\"type\":\"single\",\"secstruct\":\"(((((((((((....))))))))))).....\"}]","annotations":null,"rna_type":"single","uid":"130245","username":"calebgeniesse","userpicture":"sites/default/files/pictures/picture-130245.jpg","reward":"500","secstruct":"(((((((((((....))))))))))).....","solved-by-bot":null,"num-cleared":"11850","num-submissions":"3","id":"6502963","body":"This puzzle helps demonstrate how to reduce instability without swapping basepairs. This puzzle was adapted from a <u><a href='http://www.eternagame.org/web/puzzle/2422585/' target='_blank'>puzzle</a></u> created by <u><a href='http://www.eternagame.org/web/player/36921/' target='_blank'>hoglahoo</a></u>.\r\n\r\n\r\nCheck out the <u><a href='http://www.eternagame.org/web/puzzle/2422585/' target='_blank'>original puzzle description page</a></u> for helpful hints and tips.\r\n","locks":"xxxxxxxxxxxxxxxxxxxxxxxxxxooxxx","beginseq":"UUUUUUUUUUUAAAAGGGGGGGGGGGAAAAA","usetails":null,"constraints":"SHAPE,0","scoring":null,"folder":null,"made-by-player":"0","tutorial-level":"64","ui-specs":"{\"mission_cleared\": {\"info\": \"Sometimes bases will slide into the wrong shape - Eterna players refer to this as &quot;sliding&quot;. In the scientific literature, it's usually referred to as &quot;slipping&quot;.<br><br><img width='332' hspace='26' height='85' src='/puzzle-progression/images/sliding-example.png'><br><br><u><a target='_blank' href='http://www.eternagame.org/web/puzzle/6502963/'>Feedback</a></u>\", \"more\": \"\"}, \"mission\": {\"text\": \"Solve 11 puzzles to build your Thermocycler!\"}}","rscript":null,"type":"Progression","last-round":null,"next-puzzle":"6502964","next-puzzle-page":null,"objective":"[{\"type\":\"single\",\"secstruct\":\"(((((((((((....))))))))))).....\"}]","check_hairpin":null,"barcode_start":null,"barcode_length":null,"cloud_round":null,"hint":"You have to prevent the Us from pairing with the As. Experiment with G and C on the open bases (which don't form strong pairs with U). If you're still having trouble, ask for help in chat. You can send a screenshot of the puzzle in the settings menu. That's the button with three bars on the left part of your screen.","coauthor":"[\"Thermocycler\", 36921]","3d_structure":null,"max-votes":0},"nid":"6502963"}}