{"data":{"labs":[{"nid":"16565124","body":"Eternabind represents a new era of Eterna: a 3D interface that folds the RNA and the ligand in real time. We implemented a backend folding engine that folds your sequence together with the ligand, so you can see how the RNA wraps around it. You can also click the ligand to see potential RNA-ligand interactions. An AutoDock Vina metric calculates fold energies for each design. Naturally, these are merely estimations.<br><br>\n\nEternabind is hosted on a separate server, not the main Eterna website. To get access to the puzzle, email hlee260@stanford.edu to request permission. We’ll send you a passcode to log in and start playing.<br><br>\n\n<b>Goal</b><br>\nDesign RNA aptamers that bind six different ligands: c-di-GMP, 3'3' c-GAMP, 2'3' c-GAMP, c-AMP-UMP, c-di-UMP, and viomycin. We are requesting 50 designs for each ligand from each player. Natural binders already exist for c-di-GMP, c-GAMP, and viomycin, but none exist for c-AMP-UMP or c-di-UMP. <br><br>\n\nThe pilot round runs from October 12, 11 AM PST to October 31, 9 PM PST. We’re aiming for 1,000 designs per ligand, so please fill your 50 slots per ligand if you can! As experimental data from this round is released, we’ll develop new puzzle-solving tools to guide future attempts.","title":"Eternabind Pilot ","status":"1","created":"Oct 19, 2026","founder_uid":"246020","founder":"DigitalEmbrace","founder_picture":"sites/default/files/pictures/picture-246020.jpg","project_closes":"1793494800","total_designs":null,"banner_image":"https://eternagame.org/sites/default/files/eternabind-keyart-v2.jpg","carousel_title":"Eternabind Pilot","carousel_subtitle":"Design RNA aptamers in 3D","proposed_date":"0","synth_date":"0","num_synth":null,"affiliation":"Stanford University, Howard Hughes Medical Institute","selection":null,"cover_image":null,"cloud_round":"157","challenge":null,"restart":true,"puzzles":null,"designs_to_be_synthesized":0,"max_designs":0,"total_submitted_solutions":0,"total_submitted_solutions_of_user":0},{"nid":"16529751","body":"There have been many exciting advancements in RNA puzzle design, from analyzing solvability [<a href=\"https://arxiv.org/abs/2311.08331\">1</a>, <a href=\"https://arxiv.org/abs/2402.17206\">2</a>, <a href=\"https://arxiv.org/abs/2602.13610\">3</a>] to new algorithms like <a href=\"https://10.1093/nar/gkae1306\">DesiRNA</a> and <a href=\"https://doi.org/10.48550/arXiv.2606.07562\">Montparnasse</a>. These have all built on the Eterna100 benchmark, a set of structures of varying complexity proposed by players. Now we are proposing an even more ambitious challenge to the RNA community!\n<br/><br/>\nThis lab series collects all the Eterna puzzles solvable using Vienna1 or Vienna2 as the folding engine with a maximum of 400 nucleotides, single state/no molecule binding, which at most one player aside from the author has solved. To date, there are almost 500 of these puzzles dating as far back as 2013. We're calling this new design challenge \"Eterna Hard\". This is the second set of these puzzles which we're challenging players to solve for themselves.\n<br/><br/>\n<b>Goal</b>\n<br/>\nSolve player puzzles using the Vienna1 or Vienna2 engine to help assess how difficult each puzzle is. No wet lab experiment will be performed. As an additional incentive, we've increased the amount of points each of these puzzles is worth (if you've already solved any of them, don't worry, we've increased your point total to reflect it).\n<br/><br/>\n<b>Previous Rounds</b>\n<br/>\n<a href=\"https://eternagame.org/labs/16022932\">Group 1</a>","title":"Eterna Hard: Group 2","status":"1","created":"Sep 30, 2026","founder_uid":"48290","founder":"LFP6","founder_picture":"sites/default/files/pictures/picture-48290.jpg","project_closes":"1793494800","total_designs":null,"banner_image":"https://eternagame.org/sites/default/files/eterna-hard-keyart-v2.png","carousel_title":"Eterna Hard","carousel_subtitle":"Group 2","proposed_date":"0","synth_date":"0","num_synth":"0","affiliation":"Stanford University","selection":null,"cover_image":"https://eternagame.org/sites/default/files/eterna-hard-keyart-v2.png","cloud_round":null,"challenge":null,"restart":true,"puzzles":[{"round":1,"puzzles":["3054724","3059727","3062540","3067824","3161590","3163385","3192619","3217235","3222750","3696908","3697953","3698842","3717274","3731267","3732568","3750585","3805053","4115808","4116900","4118046","4212758","4252630","4489883","4531363","4560826","4580778","4583450","4627086","4637698","4645147","4697326","4698582","4718738","4732033","4762862","4763306","4785600","4787307","4805297","4805561","4809779","4811709","5012134","5024289","5028220","5031820","5043452","5044640","5047897","5097853","5111167","5112880","5128640","5175731","5193636","5225460","5241318","5251825","5267512","5274642","5278087","5299042","5302476","5330785","5343360","5366377","5381661","5390849","5399217","5404194","5404826","5404979","5407007","5407793","5412270","5420566","5423472","5433379","5436478","5438599","5447459","5448847","5586072","5589624","5602705","5685551","5796644","5889167","8011261","8042559","8076010","8661532","8699381","8701077","8706945","8711679","8718936","9514301","10203525","11309588"],"playable":true}],"designs_to_be_synthesized":null,"max_designs":null,"total_submitted_solutions":234,"total_submitted_solutions_of_user":0}],"num_labs":"2","num_slots":"0"}}